| 🇪🇺 Europe — UK, France, Spain, Italy | PHLDFWCLT | Philadelphia has the widest European map in the network — eighteen cities counting summer. Dallas covers the same majors from the centre of the country, Charlotte from the Southeast. JFK adds the premium A321XLR service. |
| 🇪🇺 Europe — Central and Northern (Prague, Budapest, Copenhagen, Zurich) | PHLDFW | Almost entirely Philadelphia, and almost entirely summer: Prague, Budapest, Copenhagen and Edinburgh run seasonally, Zurich year-round. Dallas adds Zurich and Amsterdam in summer. |
| 🇪🇺 Europe — Germany | CLTDFW | Charlotte–Frankfurt and Charlotte–Munich year-round; Dallas–Frankfurt year-round. American flies no other German city. |
| Japan | DFWLAXORD | Dallas has both Haneda and Narita; LA has Haneda; Chicago–Narita resumes March 27, 2027. JFK–Haneda covers the East Coast. |
| South Korea & China | DFW | Dallas only — Seoul Incheon and Shanghai Pudong. Everything else in East and Southeast Asia is a connection on a oneworld partner from ICN, HND or LHR. |
| India | JFK | JFK–Delhi is American's only India nonstop. |
| Australia & New Zealand | LAXDFW | LA–Sydney year-round; Dallas adds Brisbane and Auckland in season, and LA adds Auckland. Dallas–Sydney is not flown. |
| Middle East (Tel Aviv) | JFK | JFK–Tel Aviv resumes January 6, 2027. No other American hub flies the Middle East. |
| Africa | — | American flies no African destination from any hub. Use a oneworld partner via LHR, MAD or DOH. |
| South America — Brazil, Argentina, Chile, Peru | MIADFWJFK | Miami is the fortress: São Paulo, Rio, Buenos Aires, Santiago, Lima, Montevideo, plus Quito, Guayaquil and four Colombian cities. Dallas and JFK add São Paulo and Buenos Aires. |
| Colombia, Ecuador, Guyana | MIA | Miami flies Bogotá, Medellín, Cali, Cartagena, Barranquilla, Quito, Guayaquil and Georgetown. Dallas has Bogotá; JFK has Georgetown. |
| Central America | MIADFW | Miami has every capital plus Roatán and Liberia. Dallas covers the same countries. Charlotte and Chicago add Belize City, Guatemala City and Liberia in season. |
| 🇲🇽 Mexico | DFWMIAPHX | Dallas has thirteen Mexican cities including Morelia, Oaxaca, Querétaro and León — the deepest non-resort map any US airline flies. Miami adds Mérida and Tulum. |
| Cuba | MIA | Miami is the only US hub with Cuba: Havana, Holguín, Camagüey, Santiago de Cuba and Varadero. |
| Caribbean | MIACLTPHL | Miami serves thirty-one Caribbean airports and Charlotte eighteen — between them, effectively every island with a runway. Philadelphia and JFK cover the majors. |
| 🇨🇦 Canada | DFWCLTMIA | Toronto and Vancouver from most hubs; Montréal from Dallas and Miami; Calgary from Dallas year-round and elsewhere in summer; Halifax from Philadelphia in summer. |